
	Welcome

	CADISP Investigators

	CADISP Meetings

	CADISP-genetics association study

	CADISP Study Protocol

	CADISP therapeutic aspects

	Funding

	Publications

	Contact

	Links

Publications

Please find here below the currently available publications about CADISP:

Publications from the CADISP-group

Grond-Ginsbach C, Chen B, Krawczak M, Pjontek R, Ginsbach P, Jiang Y, Abboud S, Arnold ML, Bersano A, Brandt T, Caso V, Debette S, Dichgans M, Geschwendtner A, Giacalone G, Martin JJ, Metso AJ, Metso TM, Grau AJ, Kloss M, Lichy C, Pezzini A, Traenka C, Schreiber S, Thijs V, Touzé E, Del Zotto E, Tatlisumak T, Leys D, Lyrer PA, Engelter ST; CADISP group. Genetic Imbalance in Patients with Cervical Artery Dissection. Curr Genomics. 2017 Apr;18(2):206-213. PMID: 28367076

Traenka C, Dougoud D, Simonetti BG, Metso TM, Debette S, Pezzini A, Kloss M, Grond-Ginsbach C, Majersik JJ, Worrall BB, Leys D, Baumgartner R, Caso V, Béjot Y, Compter A, Reiner P, Thijs V, Southerland AM, Bersano A, Brandt T, Gensicke H, Touzé E, Martin JJ, Chabriat H, Tatlisumak T, Lyrer P, Arnold M, Engelter ST; CADISP-Plus Study Group. Cervical artery dissection in patients > 60 years: Often painless, few mechanical triggers. Neurology. 2017 Apr 4;88:1313-1320.

Kellert L, Kloss M, Pezzini A, Debette S, Leys D, Caso V, Thijs VN, Bersano A, Touzé E, Tatlisumak T, Traenka C, Lyrer PA, Engelter ST, Metso TM, Grond-Ginsbach C; Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) study group. Prognostic significance of pulsatile tinnitus in cervical artery dissection. Eur J Neurol. 2016 Apr 27. doi: 10.1111/ene.13031. [Epub ahead of print] PMID: 27120261

Debette S, Kamatani y, Metso TM, Kloss M, Chauhan G, Engelter ST, Pezzini A, Thijs V, Markus HS, Dichgans M, Wolf C, Dittrich R, Touzé E, Southerland AM, Samson Y, Abboud S, Béjot Y, Caso V, Bersano A, Gschwendtner A, Sessa M, Cole J, Lamy C, Medeiros E, Beretta S, Bonati LH, Grau AJ, Michel P, Majersik JJ, Sharma P, Kalashnikova L, Nazarova M, Dobrynina L, Bartels E, Guillon B, van den Herik EG, Fernandez-Cadenas I, Jood K, Nalls MA, De Leeuw FE, Jern C, Cheng YC, Werner I, Metso AJ, Lichy C, Lyrer PA, Brandt T, Boncoraglio GB, Wichmann HE, Gieger C, Johnson AD, Böttcher T, Castellano M, Arveiler D, Arfan Ikram M, Breteler MMB, Padovani A, Meschia JF, Kuhlenbäumer G, Rolfs A, Worrall BB, International Stroke Genetics Consortium, Ringelstein EB, Zelenika D, Tatlisumak T, Lathrop M, Leys D, Amouyel P, Dallongeville J for the CADISP group. Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection. Nature Genetics. 2015;47:78-83

Debette S, Compter A, Labeyrie MA, Uyttenboogaart M, Metso TM, Majersik JJ, Goeggel-Simonetti B, Engelter ST, Pezzini A, Bijlenga P, Southerland AM, Naggara O, Béjot Y, Cole JW, Ducros A, Giacalone G, Schilling S, Reiner P, Sarikaya H, Welleweerd JC, Kappelle LJ, de Borst GJ, Bonati LH, Jung S, Thijs V, Martin JJ, Brandt T, Grond-Ginsbach C, Kloss M, Mizutani T, Minematsu K, Meschia JF, Pereira VM, Bersano A, Touzé E, Lyrer PA, Leys D, Chabriat H, Markus HS, Worrall BB, Chabrier S, Baumgartner R, Stapf C, Tatlisumak T, Arnold M, Bousser MG. Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection. Lancet Neurol. 2015;14:640-54

Kellert L, Kloss M, Pezzini A, Metso TM, Metso AJ, Debette S, Leys D, Caso V, Thijs V, Bersano A, Touzé E, Tatlisumak T, Gensicke H, Lyrer PA, Bösel J, Engelter ST, Grond-Ginsbach C; Cervical Artery Dissection Ischaemic Stroke Patients (CADISP) study group. Anemia in young patients with ischaemic stroke. Eur J Neurol. 2015;22:948-53.

Béjot Y, Aboa-Eboulé C, Debette S, Pezzini A, Tatlisumak T, Engelter S, Grond-Ginsbach C, Touzé E, Sessa M, Metso T, Metso A, Kloss M, Caso V, Dallongeville J, Lyrer P, Leys D, Giroud M, Pandolfo M, Abboud S; CADISP Group. Characteristics and outcomes of patients with multiple cervical artery dissection. Stroke. 2014;45:37-41.

Debette S,* Simonetti BG,* Schilling S, Martin JJ, Kloss M, Sarikaya H, Hausser I, Engelter S, Metso TM, Pezzini A, Thijs V, Touzé E, Paolucci S, Costa P, Sessa M, Samson Y, Béjot Y, Altintas A, Metso AJ, Hervé D, Lichy C, Jung S, Fischer U, Lamy C, Grau A, Chabriat H, Caso V, Lyrer PA, Stapf C, Tatlisumak T, Brandt T, Tournier-Lasserve E, Germain DP, Frank M, Baumgartner RW, Grond-Ginsbach C, Bousser MG, Leys D, Dallongeville J, Bersano A, Arnold M; For the CADISP-plus consortium. Familial occurrence and heritable connective tissue disorders in cervical artery dissection. Neurology. 2014;83:2023-2031

Kloss M, Grond-Ginsbach C, Pezzini A, Metso TM, Metso AJ, Debette S, Leys D, Dallongeville J, Caso V, Thijs V, Bersano A, Touzé E, Bonati LH, Tatlisumak T, Arnold ML, Lyrer PA, Engelter ST; Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) Study Group. Stroke in first-degree relatives of patients with cervical artery dissection. Eur J Neurol. 2014;21:1102-1107.

Lyrer PA, Brandt T, Metso TM, Metso AJ, Kloss M, Debette S, Leys D, Caso V, Pezzini A, Bonati LH, Thijs V, Bersano A, Touzé E, Gensicke H, Martin JJ, Lichy C, Tatlisumak T, Engelter ST, Grond-Ginsbach C; Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) Study Group. Clinical import of Horner syndrome in internal carotid and vertebral artery dissection. Neurology. 2014;82:1653-1659.

Grond-Ginsbach C, Giossi A, Aksay SS, Engelter ST, Lyrer PA, Metso TM, Metso AJ, Tatlisumak T, Debette S, Leys D, Thijs V, Bersano A, Abboud S, Kloss M, Lichy C, Grau A, Pezzini A, Touzé E; CADISP group. Elevated peripheral leukocyte counts in acute cervical artery dissection. Eur J Neurol. 2013;20:1405-1410.

Engelter ST, Dallongeville J, Kloss M, Metso TM, Leys D, Brandt T, Samson Y, Caso V, Pezzini A, Sessa M, Beretta S, Debette S, Grond-Ginsbach C, Metso AJ, Thijs V, Lamy C, Medeiros E, Martin JJ, Bersano A, Tatlisumak T, Touzé E, Lyrer PA, for the Cervical Artery Dissection and Ischemic Stroke Patients (CADISP)-Study Group. Thrombolysis in Cervical Artery Dissection - Data from the Cervical Artery-Dissection and Ischemic Stroke Patients (CADISP) database. Eur J Neurol. 2012;19:1199:1206.

Kloss M, Metso A, Pezzini A, Leys D, Giroud M, Metso TM, Tatlisumak T, Lichy C, Bersano A, Abboud S, Grau A, Lyrer PA, Debette S, Dallongeville J, Martin JJ, Caso V, Grond-Ginsbach C, Engelter ST, for the CADISP Group. Towards Understanding Seasonal Variability in Cervical Artery Dissection. J Neurol. 2012;259:1662-1667.

Lichy C, Metso A, Pezzini A, Leys D, Metso T, Lyrer P, Debette S, Thijs V, Abboud S, Kloss M, Samson Y, Caso V, Sessa M, Beretta S, Lamy C, Medeiros E, Bersano A, Touze E, Tatlisumak T, Grau A, Brandt T, Engelter S, Grond-Ginsbach C; for the Cervical Artery Dissection and Ischemic Stroke Patients (CADISP)-Study Group. Predictors of delayed stroke in patients with cervical artery dissection. Int J Stroke. 2012 Dec 11. doi: 10.1111/j.1747-4949.2012.00954.x.

Metso TM, Tatlisumak T, Debette S, Dallongeville J, Engelter ST, Lyrer PA, Thijs V, Bersano A, Abboud S, Leys D, Grond-Ginsbach C, Kloss M, Touzé E, Pezzini A, Metso AJ. Migraine in cervical artery dissection and ischemic stroke patients. Neurology. 2012;78:1221-1228.

Metso AJ*, Metso TM*, Debette S, Dallongeville J, Lyrer PA, Pezzini A, Lichy C, Kloss M, Brandt T, Touzé E, Southerland AM, Worral BB, Abboud S, Leys D, Engelter S, Grond-Ginsbach C and Tatlisumak T for the CADISP group. Gender and cervical artery dissection. *These authors contributed equally to the manuscript. Eur J Neurol. 2012;19:594-602.

Debette S, Metso T, Pezzini A, Abboud S, Metso A, Leys D, Bersano A, Louillet F, Caso V, Lamy C, Medeiros E, Samson Y, Grond-Ginsbach C, Engelter ST, Thijs V, Beretta S, Béjot Y, Sessa M, Lorenza Muiesan M, Amouyel P, Castellano M, Arveiler D, Tatlisumak T, Dallongeville J; Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) Group. Association of vascular risk factors with cervical artery dissection and ischemic stroke in young adults. Circulation. 2011;123:1537-1544.

Debette S, Grond-Ginsbach C, Bodenant M, Kloss M, Engelter S, Metso T, Pezzini A, Brandt T, Caso V, Touzé E, Metso A, Canaple S, Abboud S, Giacalone G, Lyrer P, del Zotto E, Giroud M, Samson Y, Dallongeville J, Tatlisumak T, Leys D, Martin JJ, for the CADISP group. Differential features of carotid and vertebral artery dissections: the CADISP study. Neurology. 2011;77:1174-1181.

Debette S, Metso TM, Pezzini A, Engelter ST, Leys D, Lyrer P, Metso AJ, Brandt T, Kloss M, Lichy C, Hausser I, Touzé E, Markus HS, Abboud S, Caso V, Bersano A, Grau A, Altintas A, Amouyel P, Tatlisumak T, Dallongeville J, Grond-Ginsbach C; CADISP-group. CADISP-genetics: an International project searching for genetic risk factors of cervical artery dissections. Int J Stroke. 2009;4:224-230.

Engelter ST, Brandt T, Debette S, Caso V, Lichy C, Pezzini A, Abboud S, Bersano A, Dittrich R, Grond-Ginsbach C, Hausser I, Kloss M, Grau A, Tatlisumak T, Leys D, Lyrer PA for the Cervical Artery Dissection in Ischemic Stroke Patients (CADISP)-Study Group. Antiplatelets versus anticoagulation in cervical artery dissection - a review. Stroke. 2007;38:2605-2611.

Related publications

Debette S. Pathophysiology and risk factors of cervical artery dissection: what have we learnt from large hospital-based cohorts? Curr Opin Neurol. 2014;27:20-8.

Giossi A, Ritelli M, Costa P, Morotti A, Poli L, Del Zotto E, Volonghi I, Chiarelli N, Gamba M, Bovi P, Tomelleri G, Carletti M, Checcarelli N, Meneghetti G, Morra M, Chinaglia M, De Giuli V, Colombi M, Padovani A, Pezzini A. Connective tissue anomalies in patients with spontaneous cervical artery dissection. Neurology 2014, in press

Mawet J, Boukobza M, Franc J, Sarov M, Arnold M, Bousser MG, Ducros A. Reversible cerebral vasoconstriction syndrome and cervical artery dissection in 20 patients. Neurology. 2013;81:821-4.

Southerland AM, Meschia JF, Worrall BB. Shared associations of nonatherosclerotic, large-vessel, cerebrovascular arteriopathies: considering intracranial aneurysms, cervical artery dissection, moyamoya disease and fibromuscular dysplasia. Curr Opin Neurol. 2013;26:13-28.

von Babo M, De Marchis GM, Sarikaya H, Stapf C, Buffon F, Fischer U, Heldner MR, Gralla J, Jung S, Simonetti BG, Mattle HP, Baumgartner RW, Bousser MG, Arnold M. Differences and similarities between spontaneous dissections of the internal carotid artery and the vertebral artery. Stroke. 2013;44:1537-42.

Arnold M, Fischer U, Bousser MG. Treatment issues in spontaneous cervicocephalic artery dissections. Int J Stroke. 2011;6:213-8.

Pezzini A, Drera B, Del Zotto E, Ritelli M, Carletti M, Tomelleri G, Bovi P, Giossi A, Volonghi I, Costa P, Magoni M, Padovani A, Barlati S, Colombi M. Mutations in TGFBR2 gene cause spontaneous cervical artery dissection. J Neurol Neurosurg Psychiatry. 2011;82:1372-4.

Rist PM, Diener HC, Kurth T, Schürks M. Migraine, migraine aura, and cervical artery dissection: a systematic review and meta-analysis. Cephalalgia. 2011;31:886-96.

Arnold M, Kurmann R, Galimanis A, Sarikaya H, Stapf C, Gralla J, Georgiadis D, Fischer U, Mattle HP, Bousser MG, Baumgartner RW. Differences in demographic characteristics and risk factors in patients with spontaneous vertebral artery dissections with and without ischemic events. Stroke. 2010;41:802-4.

Lyrer P, Engelter S. Antithrombotic drugs for carotid artery dissection (Cochrane Review). In: The Cochrane Library, Issue 7, 2010.

Arnold M, De Marchis GM, Stapf C, Baumgartner RW, Nedeltchev K, Buffon F, Galimanis A, Sarikaya H, Mattle HP, Bousser MG. Triple and quadruple spontaneous cervical artery dissection: presenting characteristics and long-term outcome. J Neurol Neurosurg Psychiatry. 2009;80:171-4.

Arnold M, Pannier B, Chabriat H, Nedeltchev K, Stapf C, Buffon F, Crassard I, Thomas F, Guize L, Baumgartner RW, Bousser MG. Vascular risk factors and morphometric data in cervical artery dissection: a case-control study. J Neurol Neurosurg Psychiatry. 2009;80:232-4.

Debette S, Markus HS. The genetics of cervical artery dissection: a systematic review. Stroke. 2009;40:e459-66.

Debette S, Leys D. Cervical-artery dissections: predisposing factors, diagnosis, and outcome. Lancet Neurol. 2009;8:668-78.

Georgiadis D, Arnold M, von Buedingen HC, Valko P, Sarikaya H, Rousson V, Mattle HP, Bousser MG, Baumgartner RW. Aspirin vs anticoagulation in carotid artery dissection: a study of 298 patients. Neurology. 2009;72:1810-5.

Grond-Ginsbach C, Debette S. The association of connective tissue disorders with cervical artery dissections. Curr Mol Med. 2009;9:210-214.

Arnold M, Camus-Jacqmin M, Stapf C, Ducros A, Viswanathan A, Berthet K, Bousser MG. Postpartum cervicocephalic artery dissection. Stroke. 2008;39:2377-9.

Arnold M, Baumgartner RW, Stapf C, Nedeltchev K, Buffon F, Benninger D, Georgiadis D, Sturzenegger M, Mattle HP, Bousser MG. Ultrasound diagnosis of spontaneous carotid dissection with isolated Horner syndrome. Stroke. 2008;39:82-6.

Arnold M, Bousser MG, Baumgartner RW. Prognosis and safety of anticoagulation in intracranial artery dissections in adults. Stroke. 2007;38:e140; author reply e141.

Arnold M, Bousser MG, Fahrni G, Fischer U, Georgiadis D, Gandjour J, Benninger D, Sturzenegger M, Mattle HP, Baumgartner RW. Vertebral artery dissection: presenting findings and predictors of outcome. Stroke. 2006;37:2499-503.

Arnold M, Cumurciuc R, Stapf C, Favrole P, Berthet K, Bousser MG. Pain as the only symptom of cervical artery dissection. J Neurol Neurosurg Psychiatry. 2006;77:1021-4.

Arnold M, Kappeler L, Georgiadis D, Berthet K, Keserue B, Bousser MG, Baumgartner RW. Gender differences in spontaneous cervical artery dissection. Neurology. 2006;67:1050-2.

Kloss M, Wiest T, Hyrenbach S, Werner I, Arnold M-L, Lichy C, Grond-Ginsbach C. MTHFR 677TT genotype increases the risk for cervical artery dissections. J Neurol Neurosurg Psychiatry. 2006;77:951-952.

Longoni M, Grond-Ginsbach C, Grau AJ, Genius J, Debette S, Schwaninger M, Ferrarese C, Lichy C. Polymorphism of ICAM-1 gene is a risk factor for cerebral ischemia due to spontaneous cervical arterial dissection. Neurology. 2006;66:1273-1275

Martin JJ, Hausser I, Lyrer P, Busse O, Schwarz R, Schneider R, Brandt T, Kloss M, Schwaninger M, Engelter S, Grond-Ginsbach C. Familial cervical artery dissections: clinical, morphologic, and genetic studies Stroke. 2006;37:2924-2929

Pezzini A, Caso V, Zanferrari C, Del Zotto E, Paciaroni M, Bertolino C, Grassi M, Agnelli G, Padovani A. Arterial hypertension as risk factor for spontaneous cervical artery dissection. A case- control study. J Neurol Neurosurg Psychiatry. 2006;77:95-97.

Arnold M, Bousser MG. Clinical manifestations of vertebral artery dissection. Front Neurol Neurosci. 2005;20:77-86.

Grond-Ginsbach C, Debette S, Pezzini A. Genetic approaches in the study of risk factors for cervical artery dissection. In: Baumgartner RW, Bogousslavsky J, Caso V, Paciaroni M. Handbook of Cerebral Artery Dissection. Basel, S Karger AG, 2005, 30-43.

Pezzini A, Granella F, Grassi M, Bertolino C, Del Zotto E, Immovilli P, Bazzoli E, Padovani A, Zanferrari C. History of migraine and the risk of spontaneous cervical artery dissection. Cephalalgia. 2005;25:575-580.

Grond-Ginsbach C, Engelter S, Werner I, Hausser I, Muller US, Brandt T, Lyrer P. Alpha-1-antitrypsin deficiency alleles are not associated with cervical artery dissections. Neurology. 2004;62:1190-1192.

Hausser I, Muller U, Engelter S, Lyrer P, Pezzini A, Padovani A, Moormann B, Busse O, Weber R, Brandt T, Grond-Ginsbach C. Different types of connective tissue alterations associated with cervical artery dissections. Acta Neuropathol (Berl). 2004;107:509-514.

Lucas C, Lecroart JL, Gautier C, Leclerc X, Dauzat M, Leys D, Deklunder G. Impairment of endothelial function in patients with spontaneous cervical artery dissection: evidence for a general arterial wall disease. Cerebrovasc Dis. 2004;17:170-174.

Lyrer P, Engelter S. Antithrombotic drugs for carotid artery dissection. Stroke. 2004;35:613-614.

Pezzini A, Hausser I, Brandt T, Padovani A, Grond-Ginsbach C. Internal carotid artery dissection after French horn playing. Spontaneous or traumatic event? J Neurol. 2003; 250: 1004-1005.

Touzé E, Gauvrit JY, Moulin T, Meder JF, Bracard S, Mas JL, for the Multicenter Survey on Natural History of Cervical Artery Dissection. Risk of stroke and recurrent dissection after a cervical artery dissection. A multicenter study. Neurology. 2003;61:1347-1351.

Grond-Ginsbach C, Klima B, Weber R, Striegel J, Fischer C, Hacke W, Brandt T, Hausser I. Exclusion mapping of the genetic predisposition for cervical artery dissections by linkage analysis. Ann Neurol. 2002;52:359-364.

Leys D, Bandu L, Hénon H, Lucas C, Mounier-Vehier F, Rondepierre P, Godefroy O : Clinical outcome in 287 consecutive young adults (15 to 45 years) with ischemic stroke. Neurology. 2002;59:26-33.

Pezzini A, Del Zotto E, Archetti S, Negrini R, Bani P, Albertini A, Grossi M, Assanelli D, Gasparotti R, VignoloLA, Magoni M, Padovani A. Plasma homocysteine concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke. Stroke. 2002;33:664-669.

Touzé E, Gauvrit JY, Histoire naturelle des dissections des artères cervicales. Revue de la littérature et résultats préliminaires d'une enquête nationale. J. Neuroradiol. 2002;29:251-256.

Brandt T, Orberk E, Weber R, Werner I, Busse O, Müller BT, Wigger F, Grau A, Grond-Ginsbach C, Hausser I. Pathogenesis of cervical artery dissections; association with connective tissue abnormalities. Neurology. 2001;57:24-30.

Grau AJ, Brandt T, Buggle F, Orberk E, Mytilineos J, Werle E, Conradt C, Krause M, Winter R, Hacke W. Association of cervical artery dissection with recent infection. Arch Neurol. 1999;56:851-856.

Brandt T, Hausser I, Orberk E, Grau A, Hartschuh W, Anton-Lamprecht I, Hacke W. Ultrastructural connective tissue abnormalities in patients with spontaneous cervicocerebral dissections. Ann Neurol. 1998;44:281-285.

Lucas C, Moulin T, Deplanque D, Tatu L, Chavot D. Stroke patterns of internal carotid artery dissection in 40 patients. Stroke. 1998;29:2646-2648.

Giroud M, Fayolle H, André N, Dumas R, Becker F, Martin D, Baudoin N, Krause D: Incidence of internal carotid artery dissection in the community of Dijon. J Neurol Neurosurg Psychiatry. 1995;57:1443.

Leys D, Moulin Th, Stojkovic T, Begey S, Chavot D for the DONALD investigators: long term course of cervical-artery dissection. Cerebrovasc Dis. 1995;5:43-49.

Copyright © 2017. All rights reserved.
Webmaster: Sabrina Schilling

Last update: April 10th, 2018